Journal: Molecular Cancer Research
Article Title: Contrasting Features of Papillary and Chromophobe Renal Cell Carcinoma Revealed by Whole-Genome Sequencing
doi: 10.1158/1541-7786.MCR-25-0616
Figure Lengend Snippet: Summary of clinical correlations adjusted for sex, age of sampling, and stage. A, ChCC ( n = 61) and ( B ) pRCC ( n = 103). CN, copy number; MB, megabase; SNV, single-nucleotide variant; TCRA, T-cell receptor-α; WGII, whole-genome instability index;ll *, P < 0.05.
Article Snippet: We analyzed whole-genome sequencing data on 164 tumor–normal pairs from the Genomics England 100,000 Genomes Project, providing a comprehensive, high-resolution map of copy number alterations, structural variation, and key global genomic features, including mutational signatures, intratumor heterogeneity, and analysis of extrachromosomal DNA formation.
Techniques: Sampling, Variant Assay